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PET is becoming intensively used for the detection of early stages of AD by the visualisation of Abeta accumulation within the brain. However, since accumulations have already occurred and Abeta removing therapies are still not available the need for tools that aid early diagnosis or even allow risk assessment are in desperate need.
We have discovered that the ABC transporters ABCC1 and ABCB1 are major export pumps for toxic peptides from the brain via the blood-brain barrier (BBB) and the blood-choroid plexus barriers (BCPB). It is known that the function of these barriers depend on vascular integrity, age, individual medication, and diets. We investigate the use of Positron-Emission Tomography (PET) for the detection of (early) functional abrogation of the BBB and BCPB that occur before onset of disease symptoms together with our project partners from Austria.
* Project Links:
Read more about … PETAD project 2014-2018
Read more about … PETABC project 2021-2024
* Published Research Papers:
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Performance and sensitivity of [99mTc]Tc-sestamibi compared with PET radiotracers to measure P-glycoprotein function in the kidneys and liver
Mol Pharm (2024)
Hernández I, Leterrier S, Mairinger S, Stanek J, Zacher A, Breyer L, Hacker M, Zeitlinger M, Pahnke J, Tournier N, Wanek T, Langer O
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[11C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier
JCBFM (2024)
Mairinger S, Leterrier S, Filip T, Löbsch M, Pahnke J, Hernández-Lozano I, tanek J, Tournier N, Zeitlinger M, Hacker M, Langer O, Wanek Th
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Use of PET imaging to assess the efficacy of thiethylperazine to stimulate cerebral MRP1 transport activity in wild-type and APP/PS1-21 mice
Int J of Molecular Sciences (2022)
Wölfl-Duchek M, Mairinger S, Hernández-Lozano I, Filip T, Zoufal V, Löbsch M, Stanek J, Kuntner C, Wanek C, Bauer M, Pahnke J, Langer O
23(12):6514 PubMed PDF
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Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a beta-Amyloidosis Mouse Model
Int J Mol Sci (2020)
Wanek T, Zoufal V, Brackhan M, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Pahnke J, Langer O
21(21):8245 PubMed PDF -
Measurement of cerebral ABCC1 transport activity in wildtypeand APP/PS1-21 mice with positron emission tomography
Journal of Cerebral Blood Flow and Metabolism (2020)
Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O
40(5):954-965 PubMed PDF -
Imaging ABCB1 Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with 11C-Metoclopramide PET
J Nuclear Med (2020)
Zoufal V, Mairinger S, Brackhan M, Krohn M, Filip T, Sauberer M, Stanek J, Wanek T, Tournier N, Bauer M, Pahnke J, Langer O
61(7):1050-1057 PubMed PDF
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Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET
Journal of Cerebral Blood Flow and Metabolism (2020)
Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O
40(1):150-162 PubMed PDF -
Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology (2019)
Latysheva A, Emblem KR, Brandal P, Vik-Mo EO, Pahnke J, Røysland, Hald JK, Server A
epub before print PubMed PDF
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Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET
Journal of Cerebral Blood Flow and Metabolism (2019)
Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O
epub before print PubMed PDF -
Influence of multidrug resistance-associated proteins on the excretion of the ABCC1 imaging probe 6-bromo-7-[11C]methylpurine in mice
Mol Imaging Biol (2019)
Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz J, Kuntner C, Pahnke J, Langer O
epub before print PubMed PDF
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Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
Journal of Pharmaceutical Sciences (2018)
Mairinger S, Zoufal V, Wanek T, Traxl A, Erker T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O
in press PubMed PDF
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Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with Positron Emission Tomography.
Mol Pharmaceuticals (2015)
Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O
12(9):3214-25. PubMed PDF
