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25-hydroxycholesterol attenuates tumor necrosis factor alpha-induced blood-brain barrier breakdown in vitro
BBA – Mol Basis of Dis (2024)
Loiola Azevedo R, Nguyen C, Dib S, Saint-Pol J Dehouck L, Sevin E, Naudot M, Landry C, Pahnke J, Pot C, Gosselet F
online ahead PubMed PDF
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ABCC1 Is a ΔNp63 Target Gene Overexpressed in Squamous Cell Carcinoma
Int J Mol Sci (2024)
La Banca V, De Domenico S, Nicolai S, Gatti V, Scalera S, Maugeri M, Mauriello A, Montanaro M, Pahnke J, Candi E, D’Amico S, Peschiaroli A
online ahead PubMed PDF
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Evaluation of cerebrospinal fluid (CSF) and interstitial fluid (ISF) mouse proteomes for the validation and description of Alzheimer’s disease biomarkers
J Neurosci Meth (2024)
Górska AM, Santos-Garcia I, Eiriz I, Brüning, Nyman TA, Pahnke J
online ahead PubMed PDF
Open Data Access , PRIDE dataset
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First-in-human evaluation of 6-bromo-7-[11C]methylpurine, a PET tracer for assessing the function of multidrug resistance-associated proteins in different tissues
EJNMMI (2024)
Mairinger S, Jackwerth M, Chalampalakis Z, Rausch I, Weber M, Wölfl-Duchek M, Nics L, Pahnke J, Langsteger W, Hacker M, Zeitlinger M, Langer O
online ahead PubMed PDF
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Emerging Role of ABC Transporters in Glia Cells in Health and Diseases of the Central Nervous System
Cells (2024)
Villa M, Wu JY, Hansen S, Pahnke J
13(9):740 PubMed PDF
Open Data Access -
Advancing 6-bromo-7-[11C]methylpurine to clinical use: improved regioselective radiosynthesis, non-clinical toxicity data and human dosimetry estimates
EJNMMI (2024)
Mairinger S, Jackwerth M, Soukup O, Blaickner M, Decristoforo C, Nics L, Pahnke J, Hacker M, Zeitlinger M, Langer O
9(1):34 PubMed PDF -
Apolar extracts of St. John’s wort alleviate effects of β-amyloid toxicity in early Alzheimer’s disease
Int J Mol Sci (2024)
El Menuawy A, Brüning T, Eiriz I, Hähnel U, Marthe F, Möhle L, Górska AM, Santos-García I, Wangensteen H, Wu JY, Pahnke J
25(2):1301 PubMed PDF
Open Data Access -
The atorvastatin metabolite pattern in muscle tissue and blood plasma is associated with statin muscle side effects in patients with coronary heart disease; An exploratory case-control study
Arteriosclerosis Plus (2024)
Lauritzen T, Munkhaugen J, Bergan S, Peersen K, Svarstad AC, Andersen AM, Pahnke J, Husebye E, Vethe NT,
55:31-38 PubMed PDF
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Performance and sensitivity of [99mTc]Tc-sestamibi compared with PET radiotracers to measure P-glycoprotein function in the kidneys and liver
Mol Pharm (2024)
Hernández I, Leterrier S, Mairinger S, Stanek J, Zacher A, Breyer L, Hacker M, Zeitlinger M, Pahnke J, Tournier N, Wanek T, Langer O
55:31-38 PubMed PDF
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Phenoxytacrine Derivatives: Low-Toxicity Neuroprotectants Exerting Affinity to Ifenprodil-Binding Site and Cholinesterase Inhibition
Eur J Med Chem (2024)
Misiachna A, Svobodovac B, Netolicky J, Chvojkova M, Kleteckova L, Prchal L, Novak M, Hrabinova M, Kucera T, Muckova L, Moravcova S, Zdarova Karasova J, Pejchal J, Hakenova K,Hrcka Krausova B, Kolcheva M, Ladislav M, Korabecny J, Pahnke J, Valese K, Horaka M, Soukup O
266:116130 PubMed PDF
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[11C]metoclopramide is a sensitive radiotracer to measure moderate decreases in P-glycoprotein function at the blood-brain barrier
JCBFM (2024)
Mairinger S, Leterrier S, Filip T, Löbsch M, Pahnke J, Hernández-Lozano I, tanek J, Tournier N, Zeitlinger M, Hacker M, Langer O, Wanek Th
44(1):142 PubMed PDF
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Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
J Neuroinflammation (2023)
Farfara D, Sooliman M, Avrahami L,Grace T, Amram S, Rozenstein-Tsalkovich L, Trudler D, Blanga-Kanfi S, Eldar-Finkelman H, Pahnke J*, Rosenmann*, Frenkel D*
20(1):174 PubMed PDF
Open Data Access
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ABC Transporter C1 Prevents Dimethyl Fumarate from Targeting Alzheimer’s Disease
Biology (2023)
Möhle L, Stefan K, Bascuñana P, Brackhan M, Brüning T, Eiriz I, ElMenuawy A, van Genderen S, Santos-Garcia I, Gorska AM, Villa M, Wu J, Stefan SM , Pahnke J
12(7):932 PubMed PDF
Open Data Access
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TNFα Activates Liver X Receptor Signaling Pathway And Promotes Cholesterol Efflux From Human Brain Pericytes Independently of ABCA1
Int J of Molecular Sciences (2023)
Dib S, Loiola RA, Sevin E, Saint-Pol J, Shimizu F, Kanda T, Pahnke J, Gosselet F
24(6):5992 PubMed PDF -
TGFBR3L is associated with gonadotropin production in non-functioning gonadotroph pituitary neuroendocrine tumours
Pituitary (2023)
Kolnes AJ, Øystese K, Sjöstedt E, Olarescu NC, Heck A, Pahnke J, Dahlberg D, Berg-Johnsen J, Ringstad G, Casar-Borota O, Bollerslev J, Jørgensen A
26(2):227-236 PubMed PDF
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Time- and sex-dependent effects of fingolimod treatment in a mouse model of Alzheimer’s disease
Biomolecules (2023)
Bascuñana P, Brackhan M, Möhle L, Wu J, Brüning T, Eiriz I, Jansone B, Pahnke J
13(2):331 PubMed PDF
Open Data Access
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Indole derivatives as new structural class of potent and antiproliferative inhibitors of monocarboxylate transporter 1 (MCT1; SLC16A1)
J Med Chem (2023)
Puri S, Stefan K, Khan S, Pahnke J, Stefan SM, Juvale K
66(1):657-676 PubMed PDF
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HD_BPMDS—a curated binary pattern multitarget dataset of Huntington’s disease–targeting agents
J Cheminformatics (2023)
Namasivayam V, Pahnke J, Stefan SM
15(1):109 PubMed PDF
Open Data Access
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A novel Huntington’s disease assessment platform to support future drug discovery and development
Int J of Molecular Sciences (2022)
Wu J, Möhle L, Brüning T, Eiriz I, Rafehi M, Stefan K, Stefan SM, and Pahnke J
23(23):14763 PubMed PDF
Open Data Access -
Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: Anchor point for innovative Alzheimer’s disease therapeutics
Int J of Biological Macromolecules (2022)
Namasivayam V, Stefan K, Gorecki L, Korabecny J, Soukup O, Jansson PJ, Pahnke J, Stefan SM
217:775-791 PubMed PDF
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A curated binary pattern multitarget dataset of focused ATP-binding cassette transporter inhibitors
Scientific Data (2022)
Stefan SM, Jansson P, Pahnke J, Namasivayam V
9(1):44 PubMed PDF
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Use of PET imaging to assess the efficacy of thiethylperazine to stimulate cerebral MRP1 transport activity in wild-type and APP/PS1-21 mice
Int J of Molecular Sciences (2022)
Wölfl-Duchek M, Mairinger S, Hernández-Lozano I, Filip T, Zoufal V, Löbsch M, Stanek J, Kuntner C, Wanek C, Bauer M, Pahnke J, Langer O
23(12):6514 PubMed PDF -
Isotope-labeled amyloid-β does not transmit to the brain in a prion-like manner after peripheral administration
EMBO reports (2022)
Brackhan M, Calza G, Lundgren K, Bascuñana P, Brüning T, Soliymani R, Kumar R, Abelein A, Baumann M, Lalowski M, and Pahnke J
23(7):e54405 PubMed PDF -
Screening of Alzheimer’s disease with multiwavelength Stokes polarimetry in a mouse model
IEEE Transactions on Medical Imaging (2022)
Borovkova M, Sieryi O, Lopushenko I, Kartashkina I, Pahnke J, Bykov A, Meglinski I
41(4):977-982 PubMed PDF
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The Norwegian Childhood Cancer Biobank
Cancer Reports (2022)
Hermansen J, … , Pahnke J, … et al.
5(8):e1555 PubMed PDF
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Strategies to Gain Novel Alzheimer’s Disease Diagnostics and Therapeutics Using Modulators of ABCA Transporters
Free Neuropathology (2021)
Pahnke J, Bascunana P, Brackhan M, Stefan K, Namasivayam V, Koldamova R, Wu J, Möhle L, Stefan SM
2:33 PubMed PDF HTML -
Structural feature-driven pattern analysis for multitarget modulator landscapes
Bioinformatics (2021)
Namasivayam V, Stefan K, Silbermann K, Pahnke J, Wiese M, Stefan SM
38(5):1385-1392 PubMed PDF
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Binding mode analysis of ABCA7 for the prediction of novel Alzheimer’s disease therapeutics
Comp Struct Biotechnol J (2021)
Namasivayam V, Stefan K, Pahnke J#, Stefan SM#
19:6490-6504 PubMed PDF
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A new tool for the analysis of the effect of intracerebrally injected anti-amyloid-β compounds
Journal Alzheimer’s Dis (2021)
Upīte J*, Brüning T*, Möhle L, Brackhan M, Bascuñana P, Jansone B, Pahnke J
84(4):1677-1690 PubMed PDF
OSF project page
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Intraoperative DNA methylation classification of brain tumors impacts neurosurgical strategy
Neuro-Oncology Advances (2021)
Djirackor L, Halldorsson S, Niehusmann P, Leske H, Capper D, Kuschel LP, Pahnke J, Due-Tønnessen BJ, Langmoen IA, Sandberg CJ, Euskirchen P, Vik-Mo EO
10(23):8604-8613 PubMed PDF
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Godkjenning først, forskning etterpå?
Tidskriftet Den Norske Legeforeningen (2021)
Hegrand M, Pahnke J
Sep 14:141 PubMed PDF
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Development of deep learning models for microglia analyses in brain tissue using DeePathology™ STUDIO
Journal of Neuroscience Methods (2021)
Möhle L, Bascuñana P, Brackhan M, Pahnke J
364:109371 PubMed PDF -
Novel human melanoma brain metastasis models in athymic nude fox1nu mice: Site-specific metastasis patterns reflecting their clinical origin
Cancer Med (2021)
Svendsen H, Meling T, Nygaard V, Waagene S, Russnes H, Juell S, Rogne S, Pahnke J, Helseth E, Fodstad Ø, Mælandsmo GM
10(23):8604-8613 PubMed PDF
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Dimethyl fumarate does not mitigate cognitive decline and β-amyloidosis in female APPPS1 mice
Brain Res (2021)
Möhle L, Brackhan M, Bascuñana P, Pahnke J
1768:147579 PubMed PDF
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Oppdatert kunnskap om det zoonotiske potensialet av skrantesjuke ved håndtering av slakt og konsum av kjøtt
Vitenskapskomiteen for mat og miljø – VKM (2021)
Tranulis MA, Grahek-Ogden D, Kapperud G, Pahnke J
PDF
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Scaffold fragmentation and substructure hopping reveal potential, robustness, and limits of computer-aided pattern analysis (C@PA)
Comp Struct Biotechnol J (2021)
Namasivayam V, Silbermann K, Pahnke J, Wiese M, Stefan SM
19:3269-3283 PubMed PDF -
Role of ABCA7 in human health and in Alzheimer’s disease
Int J Mol Sci (2021)
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C@PA: Computer-Aided Pattern Analysis to Predict Multitarget ABC Transporter Inhibitors
J Med Chem (2021)
Namasivayam V, Silbermann K, Wiese M, Pahnke J, Stefan SM
64(6):3350-3366 PubMed PDF -
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site
Eur J Med Chem (2021)
Silbermann K, Li J, Namasivayam V, Stefan SM, Wiese M
212:113045 PubMed PDF -
Machine Learning – supported analyses improve quantitative histological assessments of β-amyloid deposits and activated microglia
Journal of Alzheimer’s Disease (2021)
Bascuñana P, Brackhan M, Pahnke J
79(2):597-605 PubMed PDF -
Corticotroph aggressive pituitary tumours and carcinomas frequently harbour ATRX mutations
J Clin Endocrinol Metab (2021)
Casar-Borota O,…, Pahnke J,…, Burman P
106(4):1183-1194 PubMed PDF
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Brain Distribution of Dual ABCB1/ABCG2 Substrates Is Unaltered in a beta-Amyloidosis Mouse Model
Int J Mol Sci (2020)
Wanek T, Zoufal V, Brackhan M, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Pahnke J, Langer O
21(21):8245 PubMed PDF -
Vesicular ATP-binding cassette transporters in human disease – relevant aspects of their organization for future drug development
Future Drug Discovery (2020)
Stefan K, Leck LYW, Namasivayam V, Bascuñana P, Huang MLH, Riss PJ, Pahnke J, Jansson PJ & Stefan SM
FDD PDF
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Superior Pyrimidine Derivatives as Selective ABCG2 Inhibitors and Broad-Spectrum ABCB1, ABCC1, and ABCG2 Antagonists
J Med Chem (2020)
Silbermann K, Li J, Namasivayam V, Baltes F, Bendas G, Stefan SM, Wiese M
63(18):10412-32 PubMed PDF -
Detection and prediction of mild cognitive impairment in Alzheimer’s disease mice
Journal of Alzheimer’s Disease (2020)
Rai SP, Bascuñana P, Brackhan M, Krohn M, Möhle L, Paarmann K, Pahnke J
77(3):1209-1221 PubMed PDF+Suppl
Data-download -
Evaluating β-amyloidosis Progression in Alzheimer’s Disease with Mueller Polarimetry
Biomedical Optics Express (2020)
Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J, Meglinski I
11(8):4509-4519 PDF
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Fingolimod as a treatment in neurologic disorders beyond multiple sclerosis
Drugs in R&D (2020)
Bascuñana P, Möhle L, Brackhan M, Pahnke J
20(3):197-20 PubMed PDF
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Using a qPCR device to screen for modulators of ABC transporter activity: A step-by-step protocol
Journal of Pharmacological and Toxicological Methods (2020)
Möhle L, Schwarzová B, Krohn M, Stefan SM, Pahnke J
104:106882 PubMed PDF
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Early cognitive training rescues remote spatial memory but reduces cognitive flexibility in Alzheimer’s disease mice
Journal of Alzheimer’s disease (2020)
Rai SP, Krohn M, Pahnke J
75(4):1301-1317 PubMed PDF+Suppl
Data-download -
The use of Stokes-Mueller polarimetry for assessment of amyloid-β progression in a mouse model of Alzheimer’s disease
SPIE (2020)
Borovkova M, Bykov A, Popov A, Pierangelo A, Novikova T, Pahnke J, Meglinski I
11234 PDF
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Cut-off values for sufficient cortisol response to low dose Short Synacthen Test after surgery for non-functioning pituitary adenoma
Acta Neurochir (2020)
Kolnes AJ, Øystese KA, Dahlberg D, Berg-Johnsen J, Niehusmann P, Pahnke J, Bollerslev J, Jørgensen AP
162(4):845-852 PubMed PDF
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High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain
Sci Rep (2020)
Abelein A, Chen G, Kitoka K, Aleksis R, Oleskovs F, Sarr M, Landreh M, Pahnke J, Nordling K, Kronqvist N, Jaudzems K, Rising A, Johansson J, Biverstål H
10(1):235 PubMed PDF
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Measurement of cerebral ABCC1 transport activity in wild-type and APP/PS1-21 mice with positron emission tomography
Journal of Cerebral Blood Flow and Metabolism (2020)
Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O
40(5):954-965 PubMed PDF -
Imaging ABCB1 Induction at the Blood-Brain Barrier of a Beta-Amyloidosis Mouse Model with 11C-Metoclopramide PET
J Nuclear Med (2020)
Zoufal V, Mairinger S, Brackhan M, Krohn M, Filip T, Sauberer M, Stanek J, Wanek T, Tournier N, Bauer M, Pahnke J, Langer O
61(7):1050-1057 PubMed PDF
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Age dependency of cerebral P-glycoprotein function in wild-type and APPPS1 mice measured with PET
Journal of Cerebral Blood Flow and Metabolism (2020)
Zoufal V, Wanek T, Krohn M, Mairinger S, Filip T, Sauberer M, Stanek J, Pekar T, Bauer M, Pahnke J, Langer O
40(1):150-162 PubMed PDF -
Generation and characterization of an Abcc1 humanized mouse model (hABCC1flx/flx) with knockout capability
Mol Pharmacology (2019)
Krohn M, Zoufal V, Mairinger S, Wanek T, Paarmann K, Brüning T, Eiriz I, Brackhan M, Langer O, Pahnke J
96(2):138-147 PubMed PDF
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Dynamic susceptibility contrast and diffusion MR imaging identify oligodendroglioma as defined by the 2016 WHO classification for brain tumors: histogram analysis approach
Neuroradiology (2019)
Latysheva A, Emblem KR, Brandal P, Vik-Mo EO, Pahnke J, Røysland, Hald JK, Server A
61(5):545-555 PubMed PDF
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Influence of multidrug resistance-associated proteins on the excretion of the ABCC1 imaging probe 6-bromo-7-[11C]methylpurine in mice
Mol Imaging Biol (2019)
Zoufal V, Mairinger S, Krohn M, Wanek T, Filip T, Sauberer M, Stanek J, Traxl A, Schuetz J, Kuntner C, Pahnke J, Langer O
21(2):306-316 PubMed PDF
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Age-related ultrastructural changes of the basement membrane in the mouse blood-brain barrier
Journal of Cellular and Molecular Medicine (2019)
Ceafalan L, Fertig TE, Gheorghe TC, Hinescu ME, Popescu BO, Pahnke J*, Gherghicenau M*
23(2):819-827 PubMed PDF
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French maritime pine bark treatment decelerates plaque development and improves spatial memory in Alzheimer’s disease mice
Phytomedicine (2019)
Paarmann K*, Prakash SR*, Krohn M, Möhle L, Brackhan M, Brüning T, Eiriz I, Pahnke J
57:39-48 PubMed PDF
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Intrinsic xenobiotic resistance of intestinal stem cell niche
Developmental Cell (2018)
Chee CY, Pahnke J, Bunte R, Adsool VA, Madan B, Virshup DM
46(6):681-695 PubMed PDF
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The concerted amyloid-beta clearance of LRP1 and ABCB1/P-gp across the blood-brain barrier is linked by PICALM
Brain Behav Immun (2018)
Storck SE, Hartz AMS, Bernard J, Wolf A, Kachlmeier A, Mahringer A, Weggen S, Pahnke J, Pietrzik CU
73:21-33 PubMed PDF
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Short-term effects of microglia-specific mitochondrial dysfunction on amyloidosis in transgenic models of Alzheimer’s disease
Journal of Alzheimer’s Disease (2018)
Steffen J, Stenzel J, Ibrahim S, Pahnke J
65(2):465-474 PubMed PDF -
ABCA7 downregulation modifies cellular cholesterol homeostasis and decreases Aβ peptide efflux in an in vitro model of the blood-brain barrier
Journal of Alzheimer’s Disease (2018)
Lamartinière Y, Boucau MC, Dehouck L, Krohn M, Pahnke J, Candela P, Gosselet F, Fenart L
64(4):1195-1211 PubMed PDF -
Humanization of the blood-brain barrier transporter ABCB1 in mice disrupts genomic locus – lessons from three unsuccessful approaches
European J Microbiol Immunol (2018)
Krohn M, Wanek T, Menet MC, Noack A, Declèves X, Langer O, Löscher L, Pahnke J
8(3):78-86 PubMed PDF
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Survival Associations Using Perfusion and Diffusion Magnetic Resonance Imaging in Patients With Histologic and Genetic Defined Diffuse Glioma World Health Organization Grades II and III
J Comput Assist Tomogr (2018)
Latysheva A, Eeg Emblem K, Server A, Brandal P, Meling TR, Pahnke J, Hald JK
42(5):807-815 PubMed PDF
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K27/G34 versus K28/G35 in histone H3-mutant gliomas: A note of caution.
Acta Neuropathol (2018)
Leske H, Rushing E, Budka H, Niehusmann P, Pahnke J, Panagopoulos I
136(1):175-176 PubMed PDF
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Corrigendum to “Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula” [Schizophr. Res. 2016 Nov;177(1-3):52-58].
Schizophrenia Res (2018)
Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J
PubMed PDF
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Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
Journal of Pharmaceutical Sciences (2018)
Mairinger S, Zoufal V, Wanek T, Traxl A, Erker T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O
115:212-222 PubMed PDF
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Structural studies of amyloid-β peptides: unlocking the mechanism of aggregation and the associated toxicity
Biochimie (2017)
Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstål H
140:176-192 PubMed PDF
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Improved method for cannula fixation for long-term intracerebral brain infusion
Journal of Neuroscience Methods (2017)
Sike Á, Wengenroth J, Upīte J, Brüning T, Eiriz I, Sántha P, Biverstål H, Jansone B, Haugen HJ, Krohn M, Pahnke J
290:145-150 PubMed PDF -
The choroid plexus in health and in disease: dialogues into and out of the brain
Neurobiology of Disease (2017)
Marques F, Sousa J, Brito A, Pahnke J, Santos C, Correia-Neves M, Palha J
107:32-40 PubMed PDF
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Expression of endogenous mouse APP modulates amyloid deposition in hAPP-transgenic mice
Acta Neuropathologica Com (2017)
Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J
5:49 PubMed PDF
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Alcheimera slimības izpētes aktualitātes
Latvijas ārsts (2017)
Jansone B, Biverstål H (Henriks Biverstols), Pahnke J (Jenss Pānke)
Feb PDF
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Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
Acta Neuropathologica Com (2016)
Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J
4(1):91 PubMed PDF -
Sideritis spp. extracts enhance memory and learning in Alzheimer’s β-amyloidosis mouse models and aged C57Bl/6 mice.
Journal of Alzheimer’s disease (2016)
Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J
53(3):967-80 PubMed PDF
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Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula.
Schizophrenia Res (2016)
Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J
177(1-3):52-58 PubMed PDF
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Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance in APP-transgenic mice.
Acta Neuropath Com (2016)
Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis J, Schlüter D, Gundelfinger E, Montag D, Seifert U, Pahnke J, Dunay IR
4:25 PubMed PDF -
Activation of mitochondrial complex II-dependent respiration is beneficial for α-synucleinopathies.
Mol Neurobiology (2016)
Fröhlich C, Zschiebsch K, Gröger V, Paarmann K, Steffen J, Thurm C, Schropp E-M, Brüning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J
53(7):4728-44 PubMed PDF
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Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with Positron Emission Tomography.
Mol Pharmaceuticals (2015)
Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O
12(9):3214-25 PubMed PDF
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Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s disease.
PLoS Genetics (2015)
Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT
11(8):e1005267 PubMed PDF
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Accumulation of murine β-amyloid mimics early Alzheimer’s disease.
Brain (2015)
Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen und Halbach O, Pahnke J
138(Pt 8):2370-82 PubMed PDF
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The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease.
Alzheimer’s & Dementia (2015)
Lill C,…, Pahnke J et al.
(12):1407-1416 PubMed
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Perfusion-SPECT in a mouse model of neurofibromatosis type 1: towards a biomarker of neurological deficits.
J Cereb Blood Flow Metab (2015)
Apostolova I, Niedzielska D, Derlin T, Koziolek EJ, Amthauer H, Salmen B, Pahnke J, Brenner W, Mautner VF, Buchert R.
35(8):1304-12 PubMed
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Cerebral ABC transporters: Common mechanisms may modulate neurodegenerative diseases and depression in elderly.
Arch Med Res (2014)
Pahnke J, Fröhlich C, Krohn M, Paarmann K, Bogdanovic N, Årsland D, Winblad B
45(8):738-43 PubMed
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Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.
Mech Ageing Dev (2014)
Bernstein HG, Hölzl G, Dobrowolny H, Hildebrand J, Trübner K, Krohn M, Bogerts B, Pahnke J
141-142C:12-21 PubMed PDF
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Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.
Am J Pathol (2014)
Lemcke S, Müller S, Möller S, Schillert A, Ziegler A, Cepok-Kauffeld S, Comabella M, Montalban X, Rülicke T, Nandakumar KS, Hemmer B, Holmdahl R, Pahnke J, Ibrahim SM
184(9):2420-9 PubMed
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Alzheimer’s and ABC transporters – new opportunities for diagnostics and treatment.
Neurobiol Dis (2014)
Pahnke J, Langer O, Krohn M
72:54–60 PubMed -
Spinal cord pathology in chronic experimental Toxoplasma gondii infection.
Eur J Microbiol Immunol (2014)
Möhle L, Parlog A, Dunay I*, Pahnke J*
*shared last authorship
20(1):65-75 PubMed PDF
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Reduced Alzheimer’s disease pathology by St. John’s wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.
Curr Alz Res (2013)
Hofrichter J*, Krohn M*, Schumacher T, Lange C, Feistel B, Walbroel B, Heinze HJ, Crockett S, Sharbel TF, Pahnke J
10(10):1057-69 PubMed PDF
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Impaired mitochondrial energy production and ABC transporter function – a crucial interconnection in dementing proteopathies of the brain.
Mech Ageing Dev (2013)
Pahnke J, Fröhlich Ch, Krohn M, Schumacher T, Paarmann K
134(10):506-15 PubMed PDF -
DNp73 Exerts Novel Function in Metastasis Initiation by Connecting LIMA1/EPLIN to the IGF1RAKT/STAT3 Pathway.
Cancer Cell (2013)
Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Fürst K, Kowtharapu BS, Engelmann D, Niemetz B, Pützer BM
24(4):512-27 PubMed
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Genomic background-related activation of microglia and reduced beta-amyloidosis in a mouse model of Alzheimer´s disease.
Eur J Microbiol Immunol (2013)
Fröhlich C, Paarmann K, Steffen J, Stenzel J, Krohn M, Heinze HJ & Pahnke J
3(1):21-27 PubMed PDF -
Mitochondrial DNA polymorphisms specifically modify cerebral ß-beta-amyloid proteostasis.
Acta Neuropath (2012)
Scheffler K*, Krohn K*, Dunkelmann T, Stenzel J, Miroux B, Ibrahim S, von Bohlen und Halbach O, Heinze HJ, Walker LC, Gsponer JA, Pahnke J
124(2):199-208 PubMed PDF
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ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.
PLoSone (2012)
Schumacher T, Krohn M, Hofrichter J, Lange C, Stenzel J, Steffen J, Dunkelmann T, Paarmann K, Fröhlich C, Uecker A, Plath AS, Sommer A, Brüning T, Heinze HJ, Pahnke J
7(4):e35613 PubMed PDF
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Efficient near-infrared in vivo imaging of Aß deposits in Alzheimer`s disease mouse models.
J Alzheimers Dis (2012)
Schmidt A, Pahnke J
30(3):651-64 PubMed PDF -
Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma.
Clin Neurol Neurosurg (2012)
Ehler J, Patejdl R, Junghanss C, Lehmitz R, Pahnke J, Großmann A, Vogelgesang S, Brüggemann M, Benecke R, Zettl UK
114(7):1102-3 PubMed
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A novel sialyl LeX expression score as potential prognostic tool in colorectal cancer.
World J Surg Oncol (2012)
Schiffmann L, Schwarz F, Linnebacher M, Prall F, Pahnke J, Krentz H, Vollmar B, Klar E
10(1):95 PubMed PDF
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Cerebral amyloid-ß proteostasis is regulated by the membrane transport protein ABCC1 in mice.
J Clin Invest (2011)
Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J
121(10):3924–3931 PubMed PDF -
Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer’s disease.
Curr Alz Res (2011)
Scheffler K, Stenzel J, Krohn M, Lange C, Hofrichter J, Schumacher T, Brüning T, Plath AS, Walker LC, Pahnke J
8(7):781-8 PubMed PDF -
Development of Alzheimer’s disease neuroimaging biomarkers using mouse models with amyloid precursor protein transgene expression.
Prog Neurobiol (2011)
Teipel S, Buchert R, Hampel H, Pahnke J
95(4):547-56 PubMed PDF
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Automated detection of amyloid-ß-related cortical and subcortical signal changes in a transgenic model of Alzheimer’s disease using high-field MRI.
J Alzheimers Dis (2011)
Teipel SJ, Kaza E, Hadlich S, Bauer A, Brüning T, Plath AS, Krohn M, Scheffler K, Walker LC, Lotze M, Pahnke J
23(2):221-37. PubMed PDF -
Evaluation of systemic targeting of RET oncogene-based aggressive MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models.
Gene Therapy (2011)
Schmidt A, Eipel C, Fürst K, Sommer N, Pahnke J, Pützer BM
18(4):418-23 PubMed
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No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia.
Mov Disorders (2011)
Kamm C, Uflacker N, AsmusF, Schrader C, Wolters A, Wittstock M, Pahnke J, Gasser T, Volkmann J, Münchau A, Hagenah J, Benecke R, Klein C, Lohmann K
26(11):2136-7 PubMed
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Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson’s disease.
J Neurogenetics (2010)
Soehn AS, Franck Th, Biskup S, Giaime E, Melle Chr, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger J, Krüger R, Gasser T; Berg D; von EggelingF, Engelender S, Alves da Costa C, Riess O
11(2):203-15 PubMed
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E2F1 determines human melanoma progression and metastasis via EGF-receptor signaling.
J Natl Cancer I (2010)
Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM
102(2):127-33 PubMed PDF
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Alzheimer’s disease and blood-brain barrier function – Why have anti-beta-amyloid therapies failed to prevent dementia progression?
Neurosci Biobehav Rev (2009)
Pahnke J, Walker L, Scheffler K, Krohn M
33(7):1099-1108 PubMed PDF
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Die Funktion der Blut-Hirn-Schranke für die Pathogenese der Alzheimer Demenz – Implikationen für immunologische Therapien zur Plaqueauflösung.
Fortschr Neurol Psyc (2009)
Pahnke J, Krohn M, Scheffler K
77:S21-24 PubMed
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Functionally relevant domains of the prion protein identified in vivo.
PLoSone (2009)
Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A
4(9):e6707 PubMed PDF -
Involvement of CNS in leukaemia and lymphomas – CSF meningeosis and immunocytochemical phenotyping.
Fortschr Neurol Psyc (2009)
Lehmitz R, Pahnke J
77:S37-38 PubMed -
In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.
BMC Neuroscience (2009)
Westman E, Spenger Ch, Öberg J, Reyer H, Pahnke J, Wahlund LO
10:33 PubMed PDF
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Transcriptome analysis in mouse tumors induced by RET-MEN2/FMTC mutations reveals subtype-specific role in survival and interference with immune surveillance.
Endocr Relat Cancer (2009)
Engelmann D, Koczan D, Ricken P, Rimpler U, Pahnke J, Li Z, Pützer B
16(1):211-24 PubMed PDF
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Clinico-pathologic function of cerebral ABC transporters – implications for the pathogenesis of Alzheimer’s disease.
Curr Alz Research (2008)
Pahnke J, Wolkenhauer O, Krohn M, Walker LC
5(4):396-405 PubMed PDF -
Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP.
Eur J Pediatr (2008)
Miksch RM, Armbrust S, Pahnke J, Fusch C
167(8):909-916 PubMed
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2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells.
Proteomics (2007)
Hoffrogge R, Beyer S, Hubner R, Mikkat S, Mix E, Scharf C, Schmitz U, Pauleweit S, Berth M, Zubrzycki I, Christoph H, Pahnke J, Wolkenhauer O, Uhrmacher A, Volker U, Rolfs A
7(1):33-46 PubMed
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Lethal recessive myelin toxicity of prion protein lacking its central domain.
EMBO J (2007)
Baumann F, Tolnay M, Brabeck C, Pahnke J, Klotz U, Niemann HH, Heikenwalder M, Rulicke T, Burkle A, Aguzzi A
4(9):e6707 PubMed PDF -
Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression.
Eur J Neurosci (2007)
Henning J, Koczan D, Glass A, Karopka T, Pahnke J, Rolfs A, Benecke R,0 Gimsa U
25(1):239-50 PubMed
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Cholestasis from malignant melanoma.
J Clin Oncol (2007)
Bramkamp M, Dedes KJ, Strobel K, Pahnke J, Breitenstein S, Clavien PA
25(6):725-6 PubMed PDF
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The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein -implications for Parkinson’s disease.
FASEB J (2007)
Marx FP, Soehn AS, Berg D, Melle C, Schiesling C, Lang M, Kautzmann S, Strauss KM, Franck T, Engelender S, Pahnke J, Dawson S, von Eggeling F, Schulz JB, Riess O, Kruger R
21(8):1759-67 PubMed PDF
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Uptake of 18F-fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis.
J Nucl Med (2007)
Wyss MT, Spaeth N, Biollaz G, Pahnke J, Alessi P, Trachsel E, Treyer V, Weber B, Neri D, Buck A
48(4):608-14 PubMed PDF
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Uptake of (18)F-fluorocholine, (18)F-fluoro-ethyl-L: -tyrosine and (18)F-fluoro-2-deoxyglucose in F98 gliomas in the rat.
Eur J Nucl Med Mol Imaging (2006)
Spaeth N, Wyss MT, Pahnke J, Biollaz G, Lutz A, Goepfert K, Westera G, Treyer V, Weber B, Buck A
33(6):673-82 PubMed
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2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM).
Proteomics (2006)
Hoffrogge R, Mikkat S, Scharf C, Beyer S, Christoph H, Pahnke J, Mix E, Berth M, Uhrmacher A, Zubrzycki IZ, Miljan E, Völker U, Rolfs A
6(6):1833-47 PubMed
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Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune Encephalomyelitis.
Am J Pathol (2006)
Vogler S, Pahnke J, Rousset S, Ricquier D, Moch H, Miroux B, Ibrahim SM
168(5):1570-5 PubMed PDF
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Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19).
Nucl Med Biol (2006)
Spaeth N, Wyss MT, Pahnke J, Biollaz G, Trachsel E, Drandarov K, Treyer V, Weber B, Neri D, Buck A
33(5):661-6 PubMed
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Lesion pathology predicts response to plasma exchange in secondary progressive MS.
Neurology (2006)
Zettl UK, Hartung HP, Pahnke A, Brueck W, Benecke R, Pahnke J
67(8):1515-6 PubMed
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3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE.
J Autoimmun (2006)
Mix E, Ibrahim SM, Pahnke J, Glass A, Mazon-Pelaez I, Lemcke S, Koczan D, Gimsa U, Bansemer S, Scheel T, Karopka T, Bottcher T, Muller J, Dazert E, Antipova V, Hoffrogge R, Wree A, Zschiesche M, Strauss U, Kundt G, Warzok R, Gierl L, Rolfs A
27(4):251-65 PubMed
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Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: Correlation with incidence, onset and severity of disease.
Hum Mol Genet (2005)
Pelaez IM, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
14(14):1977-89 PubMed PDF
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Collection of soluble variants of membrane proteins for transcriptomics and proteomics
In Silico Biol (2005)
Moeller S, Mix E, Blueggel M, Serrano-Fernandez P, Koczan D, Kotsikoris V, Kunz M, Watson M, Pahnke J, Illges H, Kreutzer M, Mikkat S, Thiesen HJ, Glocker MO, Zettl UK, Ibrahim SM
5, 295-311 PubMed
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Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
Lancet (2005)
Rolfs A, Bottcher T, Zschiesche M, Morris P, Winchester B, Bauer P, Walter U, Mix E, Lohr M, Harzer K, Strauss U, Pahnke J, Grossmann A, Benecke R
366, 1794-6 PubMed PDF -
An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy
Eur J Neurosci (2004)
Strauss U, Kole MH, Brauer AU, Pahnke J, Bajorat R, Rolfs A, Nitsch R, Deisz,RA
19, 3048-58 PubMed -
Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process
J Neuroimmunol (2004)
Pahnke J*, Mix E*, Ibrahim S*, Koczan, D, Sina, C, Bottcher, T, Thiesen, HJ, Rolfs A
151, 158-70 PubMed -
Expression of multidrug transporters in dysembryoplastic neuroepithelial tumors causing intractable epilepsy
Clin Neuropathol (2004)
Vogelgesang S, Kunert-Keil C, Cascorbi I, Mosyagin I, Schroder E, Runge U, Jedlitschky G, Kroemer HK, Oertel J, Gaab MR, Pahnke J, Walker LC, Warzok, RW
23, 223-31 PubMed -
Ceruloplasmin gene variations and substantia nigra hyperechogenicity in Parkinson disease
Neurology (2004)
Hochstrasser H, Bauer P, Walter U, Behnke S, Spiegel J, Csoti I, Zeiler B, Bornemann A, Pahnke J, Becker G, Riess O, Berg D
63, 1912-7 PubMed -
Uptake of 18F-fluorocholine, 18F-fluoroethyl-L-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat: implications for separation of radiation necrosis from tumor recurrence
J Nucl Med (2004)
Spaeth N, Wyss, MT, Weber B, Scheidegger, S, Lutz A, Verwey J, Radovanovic I, Pahnke J, Wild D, Westera G, Weishaupt D, Hermann DM, Kaser-Hotz B, Aguzzi A, Buck A
45, 1931-8 PubMed -
Wnt-5a expression in the rat neuronal progenitor cell line ST14A
Exp Brain Res (2004)
Peters S, Mix E, Bauer P, Weinelt S, Schubert B, Knoblich R, Bottcher T, Strauss U, Pahnke J, Cattaneo E, Wree A, Rolfs A
158, 189-95 PubMed -
Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
Exp Cell Res (2004)
Pahnke J, Mix E, Knoblich R, Muller J, Zschiesche M, Schubert B, Koczan D, Bauer P, Bottcher T, Thiesen HJ, Lazarov L, Wree A, Rolfs A
297, 484-94 PubMed PDF
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The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer’s disease
Curr Alzheimer Res (2004)
Vogelgesang, S, Warzok, RW, Cascorbi, I, Kunert-Keil, C, Schroeder, E, Kroemer, HK, Siegmund, W, Walker, LC, and Pahnke J
1, 121-5 PubMed PDF -
Expressionview: visualization of quantitative trait loci and gene-expression data
EnsemblGenome Biol (2003)
Fischer G, Ibrahim, SM, Brockmann, GA, Pahnke J, Bartocci, E, Thiesen, HJ, Serrano-Fernandez, P, and Moller, S
4, R77 PubMed -
McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement
Transfusion (2003)
Jung HH, Hergersberg M, Vogt M, Pahnke J, Treyer V, Rothlisberger B, Kollias SS, Russo D, and Frey BM
43, 928-38 PubMed -
Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation
J Neurosci Res (2003)
Bottcher T, Mix E, Koczan D, Bauer P, Pahnke J, Peters S, Weinelt S, Knoblich R, Strauss U, Cattaneo E, Thiesen HJ, and Rolfs A
73, 42-53 PubMed -
Cerebral beta-amyloid deposition is augmented by the -491AA promoter polymorphism in non-demented elderly individuals bearing the apolipoprotein E epsilon4 allele
Acta Neuropath (2003)
Pahnke J, Walker LC, Schroeder E, Vogelgesang S, Stausske D, Walther R, and Warzok RW
105, 25-9 PubMed -
Gene-expression profiling of experimental autoimmune encephalomyelitis
Neurochem Res (2002)
Pahnke J, Mix E, and Ibrahim SM
24, 1157-63 PubMed -
Deposition of Alzheimer’s beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
Pharmacogenetics (2002)
Vogelgesang S, Cascorbi I, Schroeder E, Pahnke J, Kroemer HK, Siegmund W, Kunert-Keil C, Walker LC, and Warzok RW
12, 535-41 PubMed
PlumX -
Activated microglia do not mediate the early deposition of Abeta in carriers of the apolipoprotein E epsilon 4 allele
Clin Neuropathol (2002)
Vogelgesang S, Schroeder E, Walker LC, Pahnke J, Naubereit A, Walther R, Stausske D, and Warzok RW
21, 99-106 PubMed -
August 2001: Sellar/suprasellar mass in a 59-year-old woman
Brain Pathol (2002)
Vogelgesang, S, Junge, MH, Pahnke J, Gaab, MR, and Warzok, RW
12, 135-6 PubMed -
Transplantation in neurodegenerative diseases – recent advances and perspectives
Nervenheilkunde (2002)
Bauer P, Knoblich R, Mix E, Pahnke J, and Rolfs A
21, 88-93 -
Treatment with nimodipine or mannitol reduces programmed cell death and infarct size following focal cerebral ischemia
Neurosurg Rev (2000)
Korenkov AI, Pahnke J, Frei K, Warzok R, Schroeder HW, Frick R, Muljana L, Piek J, Yonekawa Y, and Gaab MR
23, 145-50 PubMed -
Apolipoprotein E4 promotes the early deposition of Abeta42 and then Abeta40 in the elderly
Acta Neuropathol (2000)
Walker LC*, Pahnke J*, Madauss, M, Vogelgesang, S, Pahnke, A, Herbst, EW, Stausske, D, Walther, R, Kessler, C, and Warzok, RW
100, 36-42 PubMed
