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TARIMAD: Targeted and Improved Alzheimer’s Disease Drug Development
TARIMAD: Pokročilý vývoj léčiv na Alzheimerovu nemoc
EEA Norway grants funding for East European countries (via TACR)
2021-2024
Partners:
Jens Pahnke, University of Oslo (UiO), Norway
Ondřej Soukup, Fakultní nemocnice Hradec Králové, Czech Republic
MUDr. Peter Bauer Ph.D., Bioinova, Czech Republic
Mgr. Martin Horák Ph.D., Ústav experimentální medicíny AV ČR, v.v.i., Czech Republic
Objectives:
The aim of the project is the development of compounds for the treatment of Alzheimer´s disease
(AD). The project will include an approaches of personalized medicine during the development
process in the way that novel compounds will be tested in a disease in a dish (DiD) model derived
from AD patients.
Cílem projektu je vývoj sloučenin pro léčbu Alzheimerovy choroby (AD). Projekt bude zahrnovat
přístupy personalizované medicíny během vývojového procesu tak, aby nové sloučeniny byly
testovány na modelu disease-in-a-dish (DiD) odvozeného z pacientských vzorků.
Keywords: Alzheimer’s, drug development, ABC transporter
Resources / Links:
O. Soukup – read more….
Meetings:
Final summary meeting in Bergen (Norway), 18-19. Mar 2024
Meeting at CAS Prag and UHHK (Czech Republic), 20-22. Nov 2023
TransportDEMENTIA5 in Tromsø (Norway), 28. Aug – 1. Sep 2023
Drug Discovery Conference in Riga (Latvia), 21.-24. Sep 2022
Posters at DDC2022
Selected References:
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Phenoxytacrine Derivatives: Low-Toxicity Neuroprotectants Exerting Affinity to Ifenprodil-Binding Site and Cholinesterase Inhibition
Eur J Med Chem (2024)
Misiachna A, Svobodovac B, Netolicky J, Chvojkova M, Kleteckova L, Prchal L, Novak M, Hrabinova M, Kucera T, Muckova L, Moravcova S, Zdarova Karasova J, Pejchal J, Hakenova K,Hrcka Krausova B, Kolcheva M, Ladislav M, Korabecny J, Pahnke J, Valese K, Horaka M, Soukup O
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Physicochemistry shapes bioactivity landscape of pan-ABC transporter modulators: Anchor point for innovative Alzheimer’s disease therapeutics
Int J of Biological Macromolecules (2022)
Namasivayam V, Stefan K, Gorecki L, Korabecny J, Soukup O, Jansson PJ, Pahnke J, Stefan SM
217:775-791 PubMed PDF