NIEP

PD Pitt Frederik Niehusmann, M.D.

Email: pitt.niehusmannATmedisin.uio.no

Current Affiliations:
Consultant, University Hospital Oslo (OUS), Oslo, Norway

Former Affiliations:
2006 – 2014 – University of Bonn, Department of Neuropathology, Germany
2006 – 2007 – University of Bonn, Department of Epileptology, Germany

Academic degrees and Professional qualifications:
2013 – PD. (Docent) at the University of Bonn, Germany
2012 – Specialisation in Neuropathology
2005 – M.D. (Dr. med.) at the University of Freiburg, Medical Faculty, Germany

Education:
2005 – State Examination in Medicine
1998 – 2005 – Medical Faculty, University of Bonn, Germany
2004 – 2005 – Medical Faculty, Universidad de Santiago, Chile
2001 – 2002 – Medical Faculty, Univeridad de La Laguna, Spain

Research Fields:
– etiopathogenesis and pathomechanisms of focal epilepsy syndromes
– limbic encephalitis
– viral infections in temporal lobe epilepsy

Selected Publications:

Niehusmann P , Guido Widman, Anna M. Eis-Hübinger, Susanne Greschus, Barbara K. Robens, Alexander Grote, Albert J. Becker (2016) Non-paraneoplastic limbic encephalitis and central nervous HHV-6B reactivation: Causality or coincidence? Neuropathology. [Epub ahead of print].

Volmering E, Niehusmann P , Peeva V, Grote A, Zsurka G, Altmüller J, Nürnberg P, Becker AJ, Schoch S, Elger CE, Kunz WS (2016) Neuropathological signs of inflammation correlate with mitochondrial DNA deletions in mesial temporal lobe epilepsy. Acta Neuropathol. [Epub ahead of print].

Elkommos S, Weber B, Niehusmann P , Volmering E, Richardson MP, Goh YY, Marson AG, Elger C, Keller SS (2016) Hippocampal internal architecture and postoperative seizure outcome in temporal lobe epilepsy due to hippocampal sclerosis. Seizure. 35:65-71.

Malter MP, Bahrenberg C, Niehusmann P , Elger CE, Surges R (2016) Features of scalp EEG in unilateral mesial temporal lobe epilepsy due to hippocampal sclerosis: Determining factors and predictive value for epilepsy surgery. Clin Neurophysiol. 127:1081-7.

Johnson MR, Behmoaras J, Bottolo L, Krishnan ML, Pernhorst K, Santoscoy PL, Rossetti T, Speed D, Srivastava PK, Chadeau-Hyam M, Hajji N, Dabrowska A, Rotival M, Razzaghi B, Kovac S, Wanisch K, Grillo FW, Slaviero A, Langley SR, Shkura K, Roncon P, De T, Mattheisen M, Niehusmann P, O’Brien TJ, Petrovski S, von Lehe M, Hoffmann P, Eriksson J, Coffey AJ, Cichon S, Walker M, Simonato M, Danis B, Mazzuferi M, Foerch P, Schoch S, De Paola V, Kaminski RM, Cunliffe VT, Becker AJ, Petretto E (2015) Systems genetics identifies Sestrin 3 as a regulator of a proconvulsant gene network in human epileptic hippocampus. Nat Commun 6:6031.

Esposito L, Drexler JF, Braganza O, Doberentz E, Grote A, Widman G, Drosten C, Eis-Hübinger AM, Schoch S, Elger CE, Becker AJ, Niehusmann P (2015) Large-scale analysis of viral nucleic acid spectrum in temporal lobe epilepsy biopsies. Epilepsia. 56:234-43.

Niehusmann P , Becker AJ (2015) Histopathologie von Autoimmunenzephalitiden. Zeitschrift für Epileptologie. 28:184-189.

Gousias K, Niehusmann P, Gielen GH, Simon M (2014) Karyopherin a2 and chromosome region maintenance protein 1 expression in meningiomas: novel biomarkers for recurrence and malignant progression. J Neurooncol 118:289-96.

Schoene-Bake JC, Keller SSNiehusmann P , Volmering E, Elger C, Deppe M, Weber B (2014). In vivo mapping of hippocampal subfields in mesial temporal lobe epilepsy: relation to histopathology. Hum Brain Mapp. 35:4718-28.

Grimminger T, Pernhorst K, Surges R, Niehusmann P, Priebe L, von Lehe M,Hoffmann P, Cichon S, Schoch S, Becker AJ (2013). Levetiracetam resistance: Synaptic signatures & corresponding promoter SNPs in epileptic hippocampi. Neurobiol Dis. 60:115-25.

Niehusmann P, Becker AJ, Malter MP, Raabe A, Boström A, von der Brelie (2013) Focal cortical dysplasia type IIIc associates with multiple cerebral cavernomas. Epilepsy Res. 107:190-4.

Schäfer N, Scheffler B, Stuplich M, Schaub C, Kebir S, Rehkämper C, Mack F, Niehusmann P, Simon M, Greschus S, Kuchelmeister K, Herrlinger U, Glas M (2013). Vemurafenib for leptomeningeal melanomatosis. J Clin Oncol. 10:73-4.

Schmitz AK, Grote A, Raabe A, Urbach H, Friedman A, von Lehe M, Becker AJ, Niehusmann P (2013) Albumin storage in neoplastic astroglial elements of gangliogliomas. Seizure. 22:144-50.

Gousias K, Becker AJ, Simon M, Niehusmann P (2012) Nuclear karyopherin a2: a novel biomarker for infiltrative astrocytomas. J Neurooncol 109:545-53.

Raabe A, Schmitz AK, Pernhorst K, Grote A, von der Brelie C, Urbach H, Friedman A, Becker AJ, Elger CE, Niehusmann P (2012) Cliniconeuropathologic correlations show astroglial albumin storage as a common factor in epileptogenic vascular lesions. Epilepsia. 53:539-48.

Niehusmann P, Mittelstaedt T, Bien CG, Drexler JF, Grote A, Schoch S, Becker AJ (2010) Presence of human herpes virus 6 DNA exclusively in temporal lobe epilepsy brain tissue of patients with history of encephalitis. Epilepsia. 51:2478-83.

Niehusmann P, Seifert G, Clark K, Atas HC, Herpfer I, Fiebich B, Bischofberger J, Normann C (2010) Coincidence detection and stress modulation of spike time-dependent long-term depression in the hippocampus. J Neurosci. 30:6225-35.

Niehusmann P, Dalmau J, Rudlowski C, Vincent A, Elger CE, Rossi JE, Bien CG (2009) Diagnostic value of N-methyl-D-aspartate receptor antibodies in women with new-onset epilepsy. Arch Neurol. 66:458-64.