Publications

  • Influence of breast cancer resistance protein and P-glycoprotein on tissue distribution and excretion of Ko143 assessed with PET imaging in mice
    Journal of Pharmaceutical Sciences (2018)

    Mairinger S, Zoufal V, Wanek T, Traxl A, Erker T, Filip T, Sauberer M, Stanek J, Kuntner C, Pahnke J, Langer O
    in press PubMed PDF

  • Structural studies of amyloid-β peptides: unlocking the mechanism of aggregation and the associated toxicity
    Biochimie (2017)

    Aleksis R, Oleskovs F, Jaudzems K, Pahnke J, Biverstål H
    140:176-192 PubMed PDF

  • Improved method for cannula fixation for long-term intracerebral brain infusion
    Journal of Neuroscience Methods (2017)

    Sike Á, Wengenrothd J, Upīte J, Brüning T, Eiriz I, Sántha P, Biverstål H, Jansone B, Haugen HJ, Krohn M, Pahnke J
    290:145-150 PubMed PDF

  • The choroid plexus in health and in disease: dialogues into and out of the brain
    Neurobiology of Disease (2017)

    Marques F, Sousa J, Brito A, Pahnke J, Santos C, Correia-Neves M, Palha J
    107:32-40 PubMed PDF

  • Expression of endogenous mouse APP modulates amyloid deposition in hAPP-transgenic mice
    Acta Neuropathologica Com (2017)

    Steffen J, Krohn M, Schwitlick C, Brüning T, Paarmann K, Pietrzik CU, Biverstål H, Jansone B, Langer O, Pahnke J
    5:49 PubMed PDF

  • Alcheimera slimības izpētes aktualitātes
    Latvijas ārsts (2017)

    Jansone B, Biverstål H (Henriks Biverstols), Pahnke J (Jenss Pānke)
    Feb PDF

  • Revisiting rodent models: Octodon degus as Alzheimer’s disease model?
    Acta Neuropathologica Com (2016)

    Steffen J, Krohn M, Paarmann K, Schwitlick C, Brüning T, Marreiros R, Müller-Schiffmann A, Korth C, Braun K, Pahnke J
    4(1):91 PubMed PDF

  • Sideritis spp. extracts enhance memory and learning in Alzheimer’s β-amyloidosis mouse models and aged C57Bl/6 mice.
    Journal of Alzheimer’s disease (2016)

    Hofrichter J, Krohn M, Schumacher T, Lange C, Feistel B, Walbroel B, Pahnke J
    53(3):967-80. PubMed PDF

  • Morphometric analysis of the cerebral expression of ATP-binding cassette transporter protein ABCB1 in chronic schizophrenia: Circumscribed deficits in the habenula.
    Schizophrenia Res (2016)

    Bernstein HG, Hildebrandt J, Dobrowolny H, Steiner J, Bogerts B, Pahnke J
    177(1-3):52-58 PubMed PDF

  • Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance in APP-transgenic mice.
    Acta Neuropath Com (2016)

    Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis J, Schlüter D, Gundelfinger E, Montag D, Seifert U, Pahnke J, Dunay IR
    4:25 PubMed PDF

  • Activation of mitochondrial complex II-dependent respiration is beneficial for α-synucleinopathies.
    Mol Neurobiology (2016)

    Fröhlich C, Zschiebsch K, Gröger V, Paarmann K, Steffen J, Thurm C, Schropp E-M, Brüning T, Gellerich F, Radloff M, Schwabe R, Lachmann I, Krohn M, Ibrahim S, Pahnke J
    53(7):4728-44 PubMed PDF

  • Factors governing P-glycoprotein-mediated drug-drug interactions at the blood-brain barrier measured with Positron Emission Tomography.
    Mol Pharmaceuticals (2015)

    Wanek T, Römermann K, Mairinger S, Stanek J, Sauberer M, Filip T, Traxl A, Kuntner C, Pahnke J, Bauer F, Erker T, Löscher W, Müller M, Langer O
    12(9):3214-25. PubMed PDF

  • Suppression of somatic expansion delays the onset of pathophysiology in a mouse model of Huntington’s disease.
    PLoS Genetics (2015)

    Budworth H, Harris FR, Williams P, Lee DY, Holt A, Pahnke J, Szczesny B, Acevedo-Torres K, Ayala-Peña S, McMurray CT
    11(8):e1005267 PubMed PDF

  • Accumulation of murine β-amyloid mimics early Alzheimer’s disease.
    Brain (2015)

    Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen und Halbach O, Pahnke J
    138(Pt 8):2370-82 PubMed

  • The role of TREM2 R47H as a risk factor for Alzheimer’s disease, frontotemporal lobar degeneration, amyotrophic lateral sclerosis, and Parkinson’s disease.
    Alzheimer’s & Dementia (2015)

    Lill C,…, Pahnke J et al.
    S1552-5260(15)00122-3 PubMed

  • Perfusion-SPECT in a mouse model of neurofibromatosis type 1: towards a biomarker of neurological deficits.
    J Cereb Blood Flow Metab (2015)

    Apostolova I, Niedzielska D, Derlin T, Koziolek EJ, Amthauer H, Salmen B, Pahnke J, Brenner W, Mautner VF, Buchert R.
    doi: 10.1038/jcbfm.2015.43. PubMed

  • Cerebral ABC transporters: Common mechanisms may modulate neurodegenerative diseases and depression in elderly.
    Arch Med Res (2014)

    Pahnke J, Fröhlich C, Krohn M, Paarmann K, Bogdanovic N, Årsland D, Winblad B
    45(8):738-43. PubMed

  • Vascular and extravascular distribution of the ATP-binding cassette transporters ABCB1 and ABCC1 in aged human brain and pituitary.
    Mech Ageing Dev (2014)

    Bernstein HG, Hölzl G, Dobrowolny H, Hildebrand J, Trübner K, Krohn M, Bogerts B, Pahnke J
    141-142C:12-21. PubMed PDF

  • Nerve conduction velocity is regulated by the inositol polyphosphate-4-phosphatase II gene.
    Am J Pathol (2014)

    Lemcke S, Müller S, Möller S, Schillert A, Ziegler A, Cepok-Kauffeld S, Comabella M, Montalban X, Rülicke T, Nandakumar KS, Hemmer B, Holmdahl R, Pahnke J, Ibrahim SM
    184(9):2420-9. PubMed

  • Alzheimer’s and ABC transporters – new opportunities for diagnostics and treatment.
    Neurobiol Dis (2014)

    Pahnke J, Langer O, Krohn M
    72:54–60. PubMed

  • Spinal cord pathology in chronic experimental Toxoplasma gondii infection.
    Eur J Microbiol Immunol (2014)

    Möhle L, Parlog A, Dunay I*, Pahnke J*
    *shared last authorship
    20(1):65-75 PubMed PDF

  • Reduced Alzheimer’s disease pathology by St. John’s wort treatment is independent of hyperforin and facilitated by ABCC1 and microglia activation in mice.
    Curr Alz Res (2013)

    Hofrichter J*, Krohn M*, Schumacher T, Lange C, Feistel B, Walbroel B, Heinze HJ, Crockett S, Sharbel TF, Pahnke J
    10(10):1057-69 PubMed PDF

  • Impaired mitochondrial energy production and ABC transporter function – a crucial interconnection in dementing proteopathies of the brain.
    Mech Ageing Dev (2013)

    Pahnke J, Fröhlich Ch, Krohn M, Schumacher T, Paarmann K
    134(10):506-15 PubMed PDF

  • DNp73 Exerts Novel Function in Metastasis Initiation by Connecting LIMA1/EPLIN to the IGF1RAKT/STAT3 Pathway.
    Cancer Cell (2013)

    Steder M, Alla V, Meier C, Spitschak A, Pahnke J, Fürst K, Kowtharapu BS, Engelmann D, Niemetz B, Pützer BM
    24(4):512-27 PubMed

  • Genomic background-related activation of microglia and reduced beta-amyloidosis in a mouse model of Alzheimer´s disease.
    Eur J Microbiol Immunol (2013)

    Fröhlich C, Paarmann K, Steffen J, Stenzel J, Krohn M, Heinze HJ & Pahnke J
    Mar 1;3(1):21-27. PubMed PDF

  • Mitochondrial DNA polymorphisms specifically modify cerebral ß-beta-amyloid proteostasis.
    Acta Neuropath (2012)

    Scheffler K*, Krohn K*, Dunkelmann T, Stenzel J, Miroux B, Ibrahim S, von Bohlen und Halbach O, Heinze HJ, Walker LC, Gsponer JA, Pahnke J
    124(2):199-208 PubMed PDF

  • ABC transporters B1, C1 and G2 differentially regulate neuroregeneration in mice.
    PLoSone (2012)

    Schumacher T, Krohn M, Hofrichter J, Lange C, Stenzel J, Steffen J, Dunkelmann T, Paarmann K, Fröhlich C, Uecker A, Plath AS, Sommer A, Brüning T, Heinze HJ, Pahnke J
    7(4):e35613 PubMed PDF

  • Efficient near-infrared in vivo imaging of Aß deposits in Alzheimer`s disease mouse models.
    J Alzheimers Dis (2012)

    Schmidt A, Pahnke J
    30(3):651-64. PubMed PDF

  • Intrathecal large granular lymphocytes as an unusual presentation of a small cell T cell lymphoma.
    Clin Neurol Neurosurg (2012)

    Ehler J, Patejdl R, Junghanss C, Lehmitz R, Pahnke J, Großmann A, Vogelgesang S, Brüggemann M, Benecke R, Zettl UK
    114(7):1102-3 PubMed

  • A novel sialyl LeX expression score as potential prognostic tool in colorectal cancer.
    World J Surg Oncol (2012)

    Schiffmann L, Schwarz F, Linnebacher M, Prall F, Pahnke J, Krentz H, Vollmar B, Klar E
    10(1):95 PubMed PDF

  • Cerebral amyloid-ß proteostasis is regulated by the membrane transport protein ABCC1 in mice.
    J Clin Invest (2011)

    Krohn M, Lange C, Hofrichter J, Scheffler K, Stenzel J, Steffen J, Schumacher T, Brüning T, Plath AS, Alfen F, Schmidt A, Winter F, Rateitschak K, Wree A, Gsponer J, Walker LC, Pahnke J
    121(10):3924–3931 PubMed PDF

  • Determination of spatial and temporal distribution of microglia by 230nm-high-resolution, high-throughput automated analysis reveals different amyloid plaque populations in an APP/PS1 mouse model of Alzheimer’s disease.
    Curr Alz Res (2011)

    Scheffler K, Stenzel J, Krohn M, Lange C, Hofrichter J, Schumacher T, Brüning T, Plath AS, Walker LC, Pahnke J
    8(7):781-8. PubMed PDF

  • Development of Alzheimer’s disease neuroimaging biomarkers using mouse models with amyloid precursor protein transgene expression.
    Prog Neurobiol (2011)

    Teipel S, Buchert R, Hampel H, Pahnke J
    95(4):547-56. PubMed PDF

  • Automated detection of amyloid-ß-related cortical and subcortical signal changes in a transgenic model of Alzheimer’s disease using high-field MRI.
    J Alzheimers Dis (2011)

    Teipel SJ, Kaza E, Hadlich S, Bauer A, Brüning T, Plath AS, Krohn M, Scheffler K, Walker LC, Lotze M, Pahnke J
    23(2):221-37. PubMed PDF

  • Evaluation of systemic targeting of RET oncogene-based aggressive MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models.
    Gene Therapy (2011)

    Schmidt A, Eipel C, Fürst K, Sommer N, Pahnke J, Pützer BM
    Apr 18(4):418-23. PubMed

  • No evidence for THAP1/DYT6 variants as disease modifiers in DYT1 dystonia.
    Mov Disorders (2011)

    Kamm C, Uflacker N, AsmusF, Schrader C, Wolters A, Wittstock M, Pahnke J, Gasser T, Volkmann J, Münchau A, Hagenah J, Benecke R, Klein C, Lohmann K
    26(11):2136-7 PubMed

  • Periphilin is a novel interactor of synphilin-1, a protein implicated in Parkinson’s disease.
    J Neurogenetics (2010)

    Soehn AS, Franck Th, Biskup S, Giaime E, Melle Chr, Rott R, Cebo D, Kalbacher H, Ott E, Pahnke J, Meitinger J, Krüger R, Gasser T; Berg D; von EggelingF, Engelender S, Alves da Costa C, Riess O
    11(2):203-15 PubMed

  • E2F1 determines human melanoma progression and metastasis via EGF-receptor signaling.
    J Natl Cancer I (2010)

    Alla V, Engelmann D, Niemetz A, Pahnke J, Schmidt A, Kunz M, Emmrich S, Steder M, Koczan D, Pützer BM
    Jan 20;102(2):127-33. PubMed PDF

  • Alzheimer’s disease and blood-brain barrier function – Why have anti-beta-amyloid therapies failed to prevent dementia progression?
    Neurosci Biobehav Rev (2009)

    Pahnke J, Walker L, Scheffler K, Krohn M
    33(7):1099-1108 PubMed PDF

  • Die Funktion der Blut-Hirn-Schranke für die Pathogenese der Alzheimer Demenz – Implikationen für immunologische Therapien zur Plaqueauflösung.
    Fortschr Neurol Psyc (2009)

    Pahnke J, Krohn M, Scheffler K
    77:S21-24 PubMed

  • Functionally relevant domains of the prion protein identified in vivo.
    PLoSone (2009)

    Baumann F, Pahnke J, Radovanovic I, Rülicke T, Bremer J, Tolnay M, Aguzzi A
    4(9):e6707 PubMed PDF

  • Involvement of CNS in leukaemia and lymphomas – CSF meningeosis and immunocytochemical phenotyping.
    Fortschr Neurol Psyc (2009)

    Lehmitz R, Pahnke J
    77:S37-38 PubMed

  • In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment.
    BMC Neuroscience (2009)

    Westman E, Spenger Ch, Öberg J, Reyer H, Pahnke J, Wahlund LO
    Apr 7;10:33. PubMed PDF

  • Transcriptome analysis in mouse tumors induced by RET-MEN2/FMTC mutations reveals subtype-specific role in survival and interference with immune surveillance.
    Endocr Relat Cancer (2009)

    Engelmann D, Koczan D, Ricken P, Rimpler U, Pahnke J, Li Z, Pützer B
    16(1):211-24. PubMed PDF

  • Clinico-pathologic function of cerebral ABC transporters – implications for the pathogenesis of Alzheimer’s disease.
    Curr Alz Research (2008)

    Pahnke J, Wolkenhauer O, Krohn M, Walker LC
    5(4):396-405 PubMed PDF

  • Outcome of very low birthweight infants after introducing a new standard regime with the early use of nasal CPAP.
    Eur J Pediatr (2008)

    Miksch RM, Armbrust S, Pahnke J, Fusch C
    167(8):909-916 PubMed

  • 2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells.
    Proteomics (2007)

    Hoffrogge R, Beyer S, Hubner R, Mikkat S, Mix E, Scharf C, Schmitz U, Pauleweit S, Berth M, Zubrzycki I, Christoph H, Pahnke J, Wolkenhauer O, Uhrmacher A, Volker U, Rolfs A
    7(1):33-46 PubMed

  • Lethal recessive myelin toxicity of prion protein lacking its central domain.
    EMBO J (2007)

    Baumann F, Tolnay M, Brabeck C, Pahnke J, Klotz U, Niemann HH, Heikenwalder M, Rulicke T, Burkle A, Aguzzi A
    4(9):e6707 PubMed PDF

  • Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression.
    Eur J Neurosci (2007)

    Henning J, Koczan D, Glass A, Karopka T, Pahnke J, Rolfs A, Benecke R,0 Gimsa U
    25(1):239-50 PubMed

  • Cholestasis from malignant melanoma.
    J Clin Oncol (2007)

    Bramkamp M, Dedes KJ, Strobel K, Pahnke J, Breitenstein S, Clavien PA
    25(6):725-6 PubMed PDF

  • The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein -implications for Parkinson’s disease.
    FASEB J (2007)

    Marx FP, Soehn AS, Berg D, Melle C, Schiesling C, Lang M, Kautzmann S, Strauss KM, Franck T, Engelender S, Pahnke J, Dawson S, von Eggeling F, Schulz JB, Riess O, Kruger R
    21(8):1759-67 PubMed PDF

  • Uptake of 18F-fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis.
    J Nucl Med (2007)

    Wyss MT, Spaeth N, Biollaz G, Pahnke J, Alessi P, Trachsel E, Treyer V, Weber B, Neri D, Buck A
    48(4):608-14 PubMed PDF

  • Uptake of (18)F-fluorocholine, (18)F-fluoro-ethyl-L: -tyrosine and (18)F-fluoro-2-deoxyglucose in F98 gliomas in the rat.
    Eur J Nucl Med Mol Imaging (2006)

    Spaeth N, Wyss MT, Pahnke J, Biollaz G, Lutz A, Goepfert K, Westera G, Treyer V, Weber B, Buck A
    33(6):673-82 PubMed

  • 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM).
    Proteomics (2006)

    Hoffrogge R, Mikkat S, Scharf C, Beyer S, Christoph H, Pahnke J, Mix E, Berth M, Uhrmacher A, Zubrzycki IZ, Miljan E, Völker U, Rolfs A
    6(6):1833-47 PubMed

  • Uncoupling Protein 2 Has Protective Function during Experimental Autoimmune Encephalomyelitis.
    Am J Pathol (2006)

    Vogler S, Pahnke J, Rousset S, Ricquier D, Moch H, Miroux B, Ibrahim SM
    168(5):1570-5 PubMed PDF

  • Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19).
    Nucl Med Biol (2006)

    Spaeth N, Wyss MT, Pahnke J, Biollaz G, Trachsel E, Drandarov K, Treyer V, Weber B, Neri D, Buck A
    33(5):661-6 PubMed

  • Lesion pathology predicts response to plasma exchange in secondary progressive MS.
    Neurology (2006)

    Zettl UK, Hartung HP, Pahnke A, Brueck W, Benecke R, Pahnke J
    67(8):1515-6 PubMed

  • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE.
    J Autoimmun (2006)

    Mix E, Ibrahim SM, Pahnke J, Glass A, Mazon-Pelaez I, Lemcke S, Koczan D, Gimsa U, Bansemer S, Scheel T, Karopka T, Bottcher T, Muller J, Dazert E, Antipova V, Hoffrogge R, Wree A, Zschiesche M, Strauss U, Kundt G, Warzok R, Gierl L, Rolfs A
    27(4):251-65 PubMed

  • Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: Correlation with incidence, onset and severity of disease.
    Hum Mol Genet (2005)

    Pelaez IM, Vogler S, Strauss U, Wernhoff P, Pahnke J, Brockmann G, Moch H, Thiesen HJ, Rolfs A, Ibrahim SM
    14(14):1977-89 PubMed PDF

  • More to come soon!
    2000-2005

    Pahnke J et al.
    from – till PubMed PDF