red - ß-amyloid , green - astrocytes ...showing demyelinated white matter.Mouse model with stained Alzheimer plaques Amyloid in red, surrounding astrocytes in green Brain stem and spinal cord slices.
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    Research Topics

    project descriptions

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    scientific articles

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Welcome / Velkommen

Our research focusses on basic molecular mechanisms and new treatment options for neurodegenerative diseases with special emphasis on Alzheimer’s disease. We investigate clearance mechanisms of toxic peptides via the blood-brain barrier, new imaging  techniques, mitochondrial function, and neuroimmunological mechanisms. Our work also includes Parkinson’s, Huntington’s, ALS and other proteopathies of the brain. If you are interested to collaborate with us, please do not hesitate to get in contact.

Anwendung von Johanniskraut und Griechischem Bergtee zur Demenzbehandlung / Use of St. John’s wort and Greek Mountain tea in dementia treatment

Hier ein Link zu Rückmeldungen von Patienten / Angehörigen zu Behandlungen bei dementieller Symptomatik. Publizierte wissenschaftliche Daten finden Sie unter ‘publications’.

Externe Info-Seite zu Griechischem Bergtee
External information for Greek mountain tea

Newest press releases

1. Skal finne ut om Alzheimers smitter
Kan Alzheimers overføres fra syke til friske mennesker? Norsk forsker tror ikke det, men skal komme til bunns i.

Mer om prosjektet …

1. Forskning.no …
2. Vitenskab.dk …

2. Our team has recently published results in the prestigious scientific journal ‘BRAIN’
showing that decreased removal of toxic peptides in the brain causes the onset and first clinical signs of Alzheimer’s disease, rather than overproduction as has previously been assumed. This information can now be used to target specific genes to enhance their function in the brain of elderly or people at risk.

1. AlphaGalileo …
2. Science Daily …
3. Forskning.no …
4. Microscopy and Analysis …
5. NRK …

Krohn M, Bracke A, Avchalumov Y, Schumacher T, Hofrichter J, Paarmann K, Fröhlich C, Lange C, Brüning T, von Bohlen und Halbach Oliver, Pahnke Jens (2015): Accumulation of murine β-amyloid mimics early Alzheimer’s disease. Brain, (PubMed …, Brain …)

Norske forskere i europeisk kamp mot hjernesykdommer

En stor gruppe europeiske land og Canada bestemte seg i 2011 for å innlede en intens forskningsbasert kamp mot Alzheimer og andre hjerneødeleggende sykdommer. I 2013 fikk tre norske forskergrupper penger til å bli med i kampen, og nå har ytterligere tre norske grupper fått bevilgning.

1. Les mer om hjerneforskning i Norge og støttet grupper…(skreved av Bjarne Røsjø)
2. Les her om projektet vårt…

Information for patients and their relatives

How patients can help us:

Currently, we are investigating new genetic markers for the determination of new treatment options using ABC transport-activating drugs. We are seeking for patients and their relatives (as control group) with neurodegenerative disorders, e.g. Alzheimer’s, Parkinson’s, ALS, FTLD, Huntington’s and rare diseases. We are also looking for persons whos parents were affected by dementia. The procedure only includes a questionaire and a donation of blood. The blood can be taken by the local practitioner and then sent to us by mail. There is no need to come to our lab.

Many thanks for supporting dementia research.

Please contact us for questions:

Tel in Norway: +47 230 71466
Email: info@pahnkelab.eu